http://journal.citradharma.org/index.php/pratamamedika/issue/feedPratama Medika : Jurnal Kesehatan2023-12-16T06:01:36+00:00ismalichatinjournal.pratamamedika@gmail.comOpen Journal Systems<h1 class="page_title">Pratama Medika: Jurnal kesehatan</h1> <p><strong><span class="type">DOI: </span><span class="id">https://doi.org/10.56480/pratamamedika</span></strong></p> <p><strong>ISSN : <a href="https://manajemen-issn.lipi.go.id/publish?param=20220901401445343" target="_blank" rel="noopener">2961-9149</a></strong></p> <p><strong>Pratama Medika: Jurnal kesehatan</strong> adalah publikasi karya ilmiah di bidang kesehatan dalam arti luas seperti kesehatan masyarakat, keperawatan, kebidanan, kedokteran, farmasi, psikologi kesehatan, gizi, teknologi kesehatan, analisis kesehatan, sistem informasi kesehatan, kedokteran. catatan, manajemen rumah sakit dan sebagainya. </p> <div><strong><a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by-sa/4.0/88x31.png" alt="Creative Commons License" /></a></strong></div> <div><strong>Pratama Medika: Jurnal kesehatan</strong></div> <div>by LPI Citra Pustaka is licensed under a <a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a></div> <div> <h1 class="page_title"> </h1> <h1 class="page_title">Fokus dan Lingkup</h1> <p>Kesehatan masyarakat, keperawatan, kebidanan, kedokteran, farmasi, psikologi kesehatan, nutrisi, teknologi kesehatan, analisis kesehatan, sistem informasi kesehatan, rekam medis, hukum kesehatan , manajemen rumah sakit dll.</p> <h1 class="page_title">Diindeks oleh:</h1> <p>Dengan bangga kami umumkan bahwa Jurnal Pendidikan Bahasa dan Sastra Indonesia Metalingua telah terindeks oleh Google Scholar , Portal Garuda , ICI World of Journals , Directory of Open Access Scholarly Resources (ROAD) , Database Jurnal Ilmiah Indonesia (ISJD), Dimensions , Indonesia Onesearch , dll</p> <h1 class="page_title"><strong>Asosiasi</strong></h1> <p><em><strong>https://journal.citradharma.org/index.php/pratamamedika/Associations</strong></em></p> <h1 class="page_title"><strong>Sponsor</strong></h1> <p><em><strong>https://journal.citradharma.org/index.php/pratamamedika/Publisherandsponsors</strong></em></p> <h1 class="page_title"><strong>Penerbit</strong></h1> <p>Yayasan Citra Dharma Cindekia<strong><br />Situs : </strong><a href="https://penerbit.citradharma.org/" target="_blank" rel="noopener"><em><strong> </strong>https://www. penerbit.citradharma.org</em></a><br /><strong>Kantor Pusat</strong> : Grobogan, Jawa Tengah, 58114<br /><strong>Kantor Cabang</strong> : Jalan Kusuma Bangsa II, Kecamatan Kamal, Kabupaten Bangkalan, Jawa Timur<br /><strong>email : </strong> <em>citra.dharmacindekia@gmail.com</em><br /><strong>Telp/whatsapp</strong> : <strong>0895605883330</strong></p> </div>http://journal.citradharma.org/index.php/pratamamedika/article/view/934Testing the Activity of A Preparation of Katuk Leaf (Sauropus androgynus (L.) Merr.) Ethanol Extract Ointment on the Healing of Cut Wounds in Rabbits2023-12-12T04:43:08+00:00Poppy Ayu Holy Fitrianapoppyayu45@gmail.comSupriyanto Poppy Ayu Holy Fitrianapoppyayu45@gmail.comWahyu Purwanjani poppyayu45@gmail.com<p><em>Sauropus androgynus (L.) Merr. leaves are plants that contain secondary metabolite compounds that can be used as medicine in healing cuts. Objective: to determine the ethanol extract ointment of katuk leaves (Sauropus androgynus (L.) Merr.) for healing cuts in rabbits. Methode: the preparation of ointment preparations using the ethanol extract of katuk leaves (Sauropus androgynus (L.) Merr.) is identified for the compound content first then the ointment preparations are made. Tested using 3 (three) rabbits with 5 treatment groups, namely 10%, 12.5%, 15% katuk leaf ethanol extract ointment, positive control (10% povidone iodine), negative control (no extract base). All rabbits were injured with a length of 2cm to a depth of ± 0.2cm, each rabbit received 5 incision points. The wound is smeared 2 times a day every morning and evening. Wound observations were carried out every day for 14 days. Results Data analysis was carried out using One-Way ANNOVA. Results: Katuk leaf ethanol extract contains flavonoids, saponins and tannins. All ointment formulations have activity in healing cut wounds even though they have different healing times. Katuk leaf ethanol extract ointment meets the physical quality test requirements for ointments. The statistical test results showed that there was a significant difference in the healing of cut wounds in rabbits, namely (p<0.05). Conclusion: Katuk leaf ethanol extract ointment with a base concentration of 15% has the most optimal potential for healing cuts in rabbits.</em></p>2023-11-23T00:00:00+00:00Copyright (c) 2023 Poppy Ayu Holy Fitriana, Supriyanto, Wahyu Purwanjani http://journal.citradharma.org/index.php/pratamamedika/article/view/935Formulation of Ethanol Extract Spray Gel Preparation of Sweet Starbumber Leaves (Averrhoa carambola L.)2023-12-12T10:32:58+00:00Eka Ammyta Putri Perdantiekaammyta@gmail.comGigih Kenanga Sariekaammyta@gmail.comMaulita Saraswatiekaammyta@gmail.com<p><em>The sweet star fruit leaf plant (Averrhoa carambola L.) is a plant that has many benefits, one part of the plant that is often used is the leaves which contain alkaloids, flavonoids, saponins and tannins that can be made indo spray gel preparations. Spray gel or commonly called spray gel is a gel that has an aqueous phase of 10-90% of the weight of the spray preparation. This research aims to formulate a spray gel preparation of ethanol extract of sweet starfruit leaves (Averrhoa carambola L.) by testing the physical stability of the spray gel preparation. The formulation of spray gel preparations of sweet starfruit leaf extract (Averrhoa carambola L.) with concentrations of 0.1%, 1% and 1.5% was researched using laboratory experimental methods. Physical stability tests of spray gel preparations include organoleptic tests, pH tests, homogeneity tests, viscosity tests, spray pattern tests, dry time tests, cycling tests and centrifugation tests.The results of testing the physical stability of spray gel preparations for each formula fall within the range of requirements for spray gel preparations. To test the physical stability of the spray gel preparation after the cycling test, the viscosity test and pH test for each formula showed a decrease in each formula, while the organoleptic test did not show a significant change in each formula after the cycling test. The centrifugation test results for each formula showed that it was stable, indicated by the absence of syneresis or phase separation. Based on research, it was found that at the highest concentration the spray gel preparation of ethanol extract of sweet star fruit leaves (Averrhoa crambola L.) had a good physical stability test.</em></p>2023-11-23T00:00:00+00:00Copyright (c) 2023 Eka Ammyta Putri Perdanti, Gigih Kenanga Sari, Maulita Saraswatihttp://journal.citradharma.org/index.php/pratamamedika/article/view/936Testing the Antibacterial Activity of A Serum Preparation of Pegagan Leaf Extract (Centella asiatica (L.) Urban) Against the Bacteria Propionibacterium acnes2023-12-12T10:40:06+00:00Bela Atika Putribellaatikaputri1403@gmail.comGigih Kenanga Saribellaatikaputri1403@gmail.comMingle A Pistantybellaatikaputri1403@gmail.com<p><em>Centella asiatica (L.) Urban) is one of the wild plants and has various benefits to treat various health problems. Centella asiatica can be used as an antioxidant, antigastritis, antitumor, wound healing, immunomodulator, antiproliferation, antibacterial and so on. Purpose: To know that serum extract of Centella asiatica leaves can provide antibacterial activity of Propionibacterium acnes. Method: The research used is experimental. Centella asiatica (L.) Urban leaves were extracted by maceration with 70% ethanol. Centella asiatica (L.) Urban leaf extract was made into serum with concentrations of 5%, 10% and 15%. Physical stability tests were carried out including organoleptic, homogeneity, pH, spreadability, adhesion and viscosity, then tested for the antibacterial activity of Propionibacterium acnes. Statistical analysis was performed using the ANOVA method.</em> <em>Results: Research shows that gotu kola leaf extract contains chemical compounds including triterpenoids, saponins, flavonoids, alkaloids and tannins. The serum preparation formulation is yellowish green in color, has a distinctive extract odor and is in semisolid form, homogeneous during storage, has a pH, stickiness, spreadability, and viscosity that meet the requirements for a good serum. The results of the drag power research were F1 of 7.68% mm, F2 of 11.52 mm and F3 of 16.68 mm. The statistical test results showed a significant effect on antibacterial activity, namely <0.05.</em></p>2023-11-24T00:00:00+00:00Copyright (c) 2023 Bela Atika Putri, Gigih Kenanga Sari, Mingle A Pistantyhttp://journal.citradharma.org/index.php/pratamamedika/article/view/937Formulation and Antioxidant Test of Gotu Kola Leaf Ethanol Extract Cream (Centella asiatica)2023-12-12T10:43:16+00:00adminagus adminagusadmin@citradharma.orgVani Febri Rosianavanifebri0610@gmai.comMaulita Saraswativanifebri0610@gmai.comWahyu Purwanjanivanifebri0610@gmai.com<p><em>Cosmetic products in the form of cream preparations containing antioxidant compounds have been developed to prevent premature aging of the skin. One of these plants is the gotu kola plant which can be used as a source of natural antioxidants. The active compounds contained in gotu kola leaves are flavonoids, alkaloids, saponins, tannins, triterpenoids, terpenoids which have been developed into dosage forms suitable for cream products. To determine the formulation of gotu kola leaf extract cream as an antioxidant. This research is experimental research. This experiment is based on extraction, formulation, preparation evaluation tests including organoleptic, pH, homogeneity, viscosity, spreadability, adhesive power. Then an antioxidant test was carried out. Statistical analysis was carried out using the ANOVA method. The research results show that gotu kola leaf extract can be formulated into cream preparations with various base variations that meet the requirements for good preparation evaluation. The antioxidant test results showed the IC50 FI value was 34.04 ppm, F2 30.27 ppm, F3 26.43 ppm. Statistical test results show significant antioxidant value, namely <0.05.</em></p>2023-11-24T00:00:00+00:00Copyright (c) 2023 adminagus adminagus; Vani Febri Rosiana, Maulita Saraswati, Wahyu Purwanjanihttp://journal.citradharma.org/index.php/pratamamedika/article/view/938Serum Antibacterial Activity Test of Chinese Betel Extract (Peperomia Pellucida) Against Staphylococcus Aureus Bacteria2023-12-12T10:49:53+00:00Asri Satrianingrumasrisatrianingrum@gmail.comGigih Kenanga Sariasrisatrianingrum@gmail.comMingle A Pistantyasrisatrianingrum@gmail.com<p><em>Chinese betel is a weed plant that contains antibacterial compounds such as flavonoids, saponins, tannins, triterpenoids and alkaloids which are used as acne treatment therapy. The aim of the research is to obtain a serum with good inhibitory power from varying concentrations of 5%, 10% and 15%. , then a stability evaluation was carried out including organoleptic tests, homogeneity, pH, viscosity, spreadability and stickiness as well as testing for antibacterial activity against the growth of Staphyloccocus aureus. Data analysis was carried out using One-Way ANOVA. The results obtained from the stability test have good standards for organoleptics, homogeneity, pH, viscosity, spreadability and adhesion. Antibacterial testing showed that the diameter of the inhibition zone formed against Staphyloccocus aureus bacteria was 15.71 mm, 18.94 mm and 23.06 mm. Based on the results obtained, Chinese betel serum has good stability and all formulas can inhibit the growth of the acne-causing bacteria Staphyloccocus aureus as evidenced by the diameter of the inhibition zone formed which is in the very strong category</em></p>2023-11-24T00:00:00+00:00Copyright (c) 2023 Asri Satrianingrum, Gigih Kenanga Sari, Mingle A Pistantyhttp://journal.citradharma.org/index.php/pratamamedika/article/view/939Antibacterial Activity Test of Cat's Whiskers Leaf Extract (Sauropus androgynus (L) Merr) Serum Preparation Against Propionibacterium acnes Bacteria2023-12-12T11:05:55+00:00Maulina Nur Riskianiminglepistanty@gmail.comGigih Kenanga Sarigigihkenangasari@rocketmail.comMaulita Saraswatigigihkenangasari@rocketmail.com<p>One of the inflammatory diseases that occurs in the <em>pilosebaceous</em> unit is acne. One of the bacteria that causes acne is <em>Propionibacterium acnes</em>. Katuk leaves contain flavonoids, saponins, tannins and alkaloids which can be used as an acne treatment. One of the pharmaceutical preparations that can be used to treat acne is serum. The aim of this research is to formulate katuk leaf extract into a serum preparation, determine the physical quality characteristics of the serum preparation and then determine the antibacterial activity against <em>Propionibacterium acnes</em>.The research method used is experimental. Katuk leaves were extracted by maceration method with 70% ethanol then serum preparations were made with various extract concentrations, namely FI 40%, FII 60% and FIII 80% on the basis of serum xanthan gum. The physical quality test of the serum preparation including organoleptic, pH, homogeneity, spreadability, adhesion and viscosity was carried out, then the antibacterial activity test of Propionibacterium acnes was carried out with positive control of clindamycin 10 µg/disk, negative control of 5% DMSO using disc diffusion method. The results of this study indicate that the formula has a semi-solid form, the color of FI is brownish green, FII is dark green and FIII is blackish green with a distinctive aroma of the extract, the formulation is homogeneous, has a pH, spreadability, adhesion and viscosity that meets the requirements of a good serum. The results of the antibacterial activity test showed that the negative control had no inhibition zone, the positive control showed a strong inhibition zone of 20.09 and the katuk leaf extract serum formulation had a moderate inhibition zone of FI 18.11, FII 19.21 and FIII 19.36 the greater the inhibition zone produced due to the higher concentration of the extract made. The results of statistical analysis of variations in extract concentrations showed significant differences in the inhibition zone based on One Way Anova statistical analysis (p<0.05).</p>2023-11-24T00:00:00+00:00Copyright (c) 2023 Maulina Nur Riskiani, Gigih Kenanga Sari, Maulita Saraswati