Pratama Medika: Jurnal kesehatan DOI: https://doi.org/10.56480/pratamamedika ISSN : 2961-9149 Pratama Medika: Jurnal Kesehatan merupakan publikasi ilmiah yang didedikasikan untuk menyebarluaskan karya-karya ilmiah di bidang kesehatan dalam konteks yang luas. Jurnal ini berperan sebagai platform bagi para akademisi, peneliti, dan praktisi kesehatan untuk berbagi pengetahuan dan hasil penelitian terkini yang berhubungan dengan berbagai disiplin ilmu di sektor kesehatan. Cakupan topik yang diangkat meliputi kesehatan masyarakat, keperawatan, kebidanan, kedokteran, farmasi, psikologi kesehatan, gizi, teknologi kesehatan, analisis kesehatan, sistem informasi kesehatan, catatan medis, serta manajemen rumah sakit, dan bidang-bidang terkait lainnya. Dengan ISSN: 2961-9149, Pratama Medika berkomitmen untuk menyediakan konten yang berkualitas dan relevan, yang dapat memberikan kontribusi signifikan terhadap pengembangan ilmu pengetahuan dan praktik kesehatan. Jurnal ini juga terbuka untuk artikel-artikel yang menyajikan inovasi, aplikasi teknologi baru, atau pendekatan interdisipliner yang dapat meningkatkan kualitas layanan kesehatan. Melalui penerbitan yang dapat diakses secara daring melalui DOI: https://doi.org/10.56480/pratamamedika, jurnal ini bertujuan untuk memperluas dampak penelitiannya dan menjangkau audiens global, baik dari kalangan akademik maupun praktisi kesehatan. Pratama Medika: Jurnal kesehatan by LPI Citra Pustaka is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License Fokus dan Lingkup Kesehatan masyarakat, keperawatan, kebidanan, kedokteran, farmasi, psikologi kesehatan, nutrisi, teknologi kesehatan, analisis kesehatan, sistem informasi kesehatan, rekam medis, hukum kesehatan , manajemen rumah sakit dll. Diindeks oleh: Dengan bangga kami umumkan bahwa Jurnal Pendidikan Bahasa dan Sastra Indonesia Metalingua telah terindeks oleh Google Scholar , Portal Garuda , ICI World of Journals , Directory of Open Access Scholarly Resources (ROAD) , Database Jurnal Ilmiah Indonesia (ISJD), Dimensions , Indonesia Onesearch , dll Asosiasi https://journal.citradharma.org/index.php/pratamamedika/Associations Sponsor https://journal.citradharma.org/index.php/pratamamedika/Publisherandsponsors Penerbit Yayasan Citra Dharma Cindekia Situs : https://www. penerbit.citradharma.org Kantor Pusat : Grobogan, Jawa Tengah, 58114 Kantor Cabang : Jalan Kusuma Bangsa II, Kecamatan Kamal, Kabupaten Bangkalan, Jawa Timur email : citra.dharmacindekia@gmail.com Telp/whatsapp : 0895605883330
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Uji Aktivitas Penyembuhan Luka Bakar Salep Ekstrak Etanol Buah Parijoto (Medinilla Speciose) pada Punggung Kelinci
Medinilla speciosa contains flavonoids, saponins, tannins and alkaloids which have activity as anti-biofilm, antibacterial, antioxidant, antiseptic and play a role in tissue regeneration in the wound healing process. This study aimed to prove the activity of M. speciosa fruit made in ointment and its optimal concentration in healing second degree burns. This research was an experimental study in the laboratory to analyze the secondary metabolite content of flavonoids, saponins, tannins, alkaloids, and the burn wound healing activity of M. speciosa ethanol. This research used 3 rabbits as test animals and created 5 standardized wound locations on the rabbits' backs. Wound standardization was carried out using a heated 2 cm diameter metal plate. At 5 wound locations, each was given a test ointment preparation with a concentration of 0.075%, 0.15%, 0.30%, ointment base (negative control), and mebo ointment (positive control) for 10 days with the parameter measured being the diameter of the wound. The physical properties of the ointment include organoleptic tests, homogeneity, viscosity, spreadability and adhesiveness. The data obtained was analyzed statistically using analysis of variance. The result of this research were the all concentrations of M. speciosa fruit ethanol extract ointment showed a burn healing effect. The best wound healing based on statistical data results was shown by M. speciosa fruit extract ointment with a concentration of 0.30% with an average percentage of wound diameter closure that was the same as the positive control, namely 100% on day 10.
Copyright (c) 2024 Harimuddin, Maulita Saraswati, Supriyanto https://creativecommons.org/licenses/by-sa/4.0
Formulasi Dan Uji Aktivitas Antioksidan Sediaan Body Scrub Ekstrak Etanol 70% Daun Salam (Syzygium Polyantum)
Body scrub is a liquid or semi-solid dosage form in the form of an emulsion to remove dead skin cell dirt and provide skin moisture. Bay leaves (Syzygium polyantum) are also used as medicine. It is found that bay leaf extract has very strong antioxidant activity. Bay leaves contain alkaloids, flavonoids, tannins and saponins. This research carried out the formulation and antioxidant activity test of 70% ethanol extract of bay leaves with concentrations of 10%, 15% and 20%. Body Scrub was tested for antioxidants with vitamin C as a comparison. The goal this research was to find out that a body scrub with 70% ethanol extract of S. polyantum could make the skin soft and moist and improved the skin. This research was conducted experimentally. Tests in this research include organoleptic tests, pH, viscosity, homogeneity, spreadability, stickiness, and antioxidant activity tests. Bay leaf extract with concentrations of 10%, 15% and 20%. The results showed that the antioxidant activity of bay leaves according to the IC50 value showed that formula 3 has an IC50 value ranging between 177.338 ± 45.14 ppm and had a weak category value, while formula 1 and formula 2 respectively had an IC50 value of 550.25 ± 169.24 ppm; 362.07±122.08 ppm in the very weak category. The conclusion was the highest body scrub preparation formula for 70% ethanol extract of bay leaves was Formula III with a concentration of 20% with an IC50 value of 177.338 ± 45.14 ppm (weak category).
Copyright (c) 2024 Tanti Sulistiyorini, Wahyu Purwanjani , Maulita Saraswati https://creativecommons.org/licenses/by-sa/4.0
Formulasi dan Uji Stabilitas Fisik Sediaan Serum Ekstrak Etanol 96% Biji Alpukat (Persea americana Mill)
Research on the formulation and physical stability test of 96% ethanol extract serum preparations from avocado seeds (Persea americana Mill). This study aimed to evaluate the physical stability of several serum preparation formulations of avocado seed ethanol extract with different concentrations. The research method was 5 kg of avocado seeds). Experimental research to determine whether 96% ethanol extract of avocado seeds using three concentrations, namely 5%, 7.5% and 10%, could be formulated into a facial serum preparation. This research used a physical stability test method for serum preparations used the cycling test method, which includes organoleptic tests, pH tests, homogeneity tests, viscosity tests, spreadability tests and adhesion tests. The results showed that the secondary metabolite compounds contained in the 96% ethanol extract of avocado seeds were alkaloids, flavonoids, saponins, tannins, steroids or triterpenoids; 96% ethanol extract of avocado seeds could be formulated as a serum preparation, and the stability test results of all serum preparation formulations had good standards for organoleptics, homogeneity, pH, viscosity, spreadability and adhesiveness. The F2 serum preparation (glycerin concentration 7.5%) experienced small changed, so the stability of the F2 serum preparation was better than other preparations. Ethanol extract of avocado seeds could be made into a serum formulation, F2 formulation which had the best physical stability.
Copyright (c) 2024 Atik Rohmanah, Gigih Kenanga Sari, Estuningtyas Ayu Hapsari https://creativecommons.org/licenses/by-sa/4.0
Uji Aktivitas Antioksidan Sediaan Face Mist Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus)
Dragon fruit skin contains compounds that can be useful as antioxidants such as betalain and anthocyanin. The amount of high antioxidant content of red dragon fruit skin is able to slow, delay, or prevent the occurrence of free radical reaction processes that make humans experience premature aging. Face mist temasuk in cosmetic skin freshener that serves to refresh the facial skin, remove the remaining oil from the skin that may still exist, as well as deinfekta mild and at the same time can help cover the pores back. This study was conducted to develop red dragon fruit skin extract (Hylocereus polyrhizus) Face mist preparation as an antioxidant with a variant concentration of red dragon fruit skin extract (Hylocereus polyrhizus).Red dragon fruit skin extract (Hylocereus polyrhizus) using maceration extraction process, then extract with concentration variants 1%, 2%, 3% prepared face mist. Vitamin C as positive control and base face Mist as negative control. After obtained comparison of data processed statistically with one-way ANOVA using SPSS 22.Face mist preparation red dragon fruit skin extract (Hylocereus polyrhizus) has antioxidant activity.3% concentration of face mist preparation red dragon fruit skin extract (Hylocereus polyrhizus) contains the highest antioxidant.
Copyright (c) 2024 Fatimatul Muzayanah, Maulita Saraswati, Supriyanto https://creativecommons.org/licenses/by-sa/4.0
Uji Antioksidan Ekstrak Etanol 70%, N-Heksan, Etil Asetat Biji Alpukat (Persea Americana Mill) dengan Metode DPPH
Avocado (Persea americana Mill) is a fruit that is popular with many people, because it contains various nutrients. However, the use of avocados is not accompanied by the use of the seeds. Avocado seeds are usually used as antioxidants. Antioxidants are substances that the body needs to neutralize free radicals and prevent damage caused by free radicals. The aim of this research was to determine the antioxidant activity of avocado seed extract (Persea americana Mill) using the DPPH method. Avocado seed extract was extracted by soxhletation with different solvents 70% ethanol, n-hexane, and ethyl acetate. The extract obtained was identified for chemical compound content. Test antioxidant activity using the DPPH method to determine a good IC50 value. Based on the research results, the antioxidant test with different solvents that obtained a good IC50 value was n-hexane solvent with an IC50 value of 2.14µg/ml. The conclusion of the research is that good antioxidant test results with n-hexane solvent obtained an IC50 value of 2.14µg/ml, the lower the IC50 value, the higher the antioxidant.
Copyright (c) 2024 Putri Wahyu Ningrum, Supriyanto, Estuningtyas Ayu Hapsari https://creativecommons.org/licenses/by-sa/4.0
Antibacterial Activity Test on Face Toner Preparations 70% Ethanol Extract of Avocado Leaves (Persea americana Mill) Against Staphylococcus Aureus Bacteria
Improper use of antibiotics will cause resistance in bacteria so that other alternatives are needed such as the use of avocado plants as antibacterial plants. To determine the antibacterial activity of avocado leaf ethanol extract on the growth of Staphylococcus aureus bacteria. Laboratory experimental research to see the antibacterial activity of ethanol extract and avocado leaf fractions with concentrations of 15%, 20% and 25%. Antibacterial activity tests were carried out using the disk diffusion method against Staphylococcus aureus and comparing the inhibition zones formed from each treatment with the positive control, namely Tetracycline. The inhibition power obtained was then analyzed using the One Way Anova statistical method. The content of 70% avocado leaf ethanol extract compounds consists of flavonoids, saponins, tannins, alkaloids and terpenoids. Face toner preparation of 70% ethanol extract of avocado leaves F1 (15%) has 11.5mm, F2 (20%) has 15.7 mm and F3 (25%) has 21.4% antibacterial activity against the growth of Staphylococcus aureus bacteria. Formula 3 with a concentration of 25% with an inhibition zone of 21.4 mm has the most optimal antibacterial activity against Staphylococcus aureus bacteria. The most optimal avocado leaf face toner preparation as an antibacterial activity for Staphylococcus aureus is a concentration of 25%.
Copyright (c) 2024 Wendy Mayasari Kalalo, Wahyu Purwanjani , Supriyanto https://creativecommons.org/licenses/by-sa/4.0
Uji Aktivitas Anti Aging Sediaan Gel Ekstrak Etanol 70 % Daun Salam (Syzygium polyanthum)
Aging causes the skin to become wrinkled. The cause of aging is free radicals, free radicals in the form of UV-A rays. Bay leaf (Syzygium polyanthum) is a plant that contains flavonoid compounds which can act as antioxidants which can provide anti-aging activity. This test was carried out to find out that bay leaf extract gel was able to provide anti-aging activity. Methodology; The bay leaf extract was tested to be ethanol free and the chemical compound content was identified. The gel preparation was made using bay leaf extract with a concentration of 1.5%, 3%, 4.5%, which was tested for stability including organoleptic test, homogeneity test, pH test, adhesive test, viscosity test, and spreadability test and tested for anti-aging activity. includes percent collagen, percent elasticity, percent moisture.Results; The results of the FI, FII, and FIII gel stability tests meet the requirements for gel preparations including: pH test, viscosity test, adhesion test, and spreadability test. The results of testing the anti-aging activity of the bay leaf extract gel preparation with a concentration of 4.5% provided the most effective anti-aging effect. Conclusion; The results of the FI, FII, and FIII bay leaf extract gel tests had good stability. anti-aging activity test of bay leaf extract gel preparation with a concentration of 4.5% provided the most effective anti-aging effect.
Copyright (c) 2024 Anik Wahyuni, Wahyu Purwanjani , Supriyanto https://creativecommons.org/licenses/by-sa/4.0
Test For Antioxidant Activity Of Hair Tonic Preparations Ethanol Extract 70% Pegagan Leaves (Centella asiatica (L.) Urban)
Gotu kola leaves (Centella asiatica (L.) Urban) are wild plants that grow in various places such as fields, plantations and in yards. Gotu kola leaves contain compounds such as polyphenols, β-carotene, tannins, vitamin C and saponins such as Madecassida and Asiaticoside. The asiaticoside found in gotu kola functions as an antioxidant that can capture free radicals. Objective: To determine the 70% ethanol extract of gotu kola leaves (Centella asiatica (L.) Urban) as a hair tonic as an antioxidant using different concentration variants. Method: This research is an experimental study by testing the antioxidant activity of a hair tonic preparation of gotu kola leaf extract (Centella asiatica (L.) Urban) in a hair tonic preparation on antioxidants using the DPPH 2,2 diphenyl-1-pikeylhydrazyl method. The 70% ethanol extract of gotu kola leaves was obtained using the maceration method with 70% ethanol solvent where the thick extract obtained was tested for its compound content. Then the extract with a concentration of 5ml, 10ml, 15ml was made into a hair tonic preparation after which it was tested for physical quality, organoleptic test, homogeneity test, pH test , viscosity test, specific gravity test. Vitamin C as a positive control and hair tonic base as a negative control. After obtaining comparisons, the data were processed statistically using ANOVA. Results: This research shows that the 70% ethanol extract of gotu kola leaves (Centella asiatica (L.) Urban) contains the chemical compounds triterpenoids, flavonoids, saponins, alkaloids and tannins. All hair tonic formulations have antioxidant activity based on the IC50 value. The statistical test results show that there is a significant difference in antioxidant activity, namely (p<0.05).
Copyright (c) 2024 Lazaely Anggita Mayasari, Supriyanto, Estuningtyas Ayu Hapsari https://creativecommons.org/licenses/by-sa/4.0
Uji Aktivitas Antibakteri Serum Ekstrak Etanol 70% Daun Turi Putih (Sesbania grandiflora L) Terhadap Bakteri Staphylococcus Aureus
White turi is a plant that contains active substances that act as antibacterials, including saponins, flavonoids and tannins which can inhibit the growth of Staphylococcus aureus bacteria. Currently, the use of natural ingredients in cosmetic preparations has been developed. One of the cosmetic preparations that has developed recently is serum. This study aims to determine the antibacterial activity of serum 70% ethanol extract of white turi leaves (Sesbania grandiflora L) against Staphylococcus aureus bacteria. This research method is experimental research. White turi leaves were extracted using the maceration method with 70% ethanol solvent. The 70% ethanol extract of white turi leaves was made into serum with a concentration of 2%, 4%, 8% and the physical quality was evaluated including organoleptic tests, homogeneity, pH, spreadability, viscosity and the antibacterial activity of the serum was tested using the paper disk diffusion method. The results of the research on the formulation of the serum preparation are brownish yellow in color, have a distinctive odor of 70% ethanol extract of white turi leaves and are slightly thick, homogeneous, with a pH value = 5.65-5.86, spreadability = 5.3-6.33, viscosity = 341.66-466.46 and the inhibition zone for antibacterial activity of formula 1 is 9.48 mm (medium), formula 2 is 12.50 mm (strong) and formula 3 is 14.46 mm (strong). Based on the results obtained, it can be concluded that all serum formulas of 70% ethanol extract of white turi leaves can inhibit the growth of Staphylococcus aureus bacteria in the medium-strong category and the serum formula of 70% ethanol extract of white turi leaves (Sesbania grandiflora L) has the best activity on growth. Staphylococcus aureus bacteria is formula 3 with a concentration of 8% with an inhibition zone of 14.46 mm (strong).
White turi leaves, Extract, Serum, Staphylococcus aureus.
Copyright (c) 2024 Dita Purnama https://creativecommons.org/licenses/by-sa/4.0
Testing The Antibacterial Activitiy of A Facial Wash Preparation of Sweet Belimbing Leaf Extract (Averrhoa Carambola L.) Against The Bacteria Sthapyloccocus Epidermidi
Facial wash or what is usually called facial cleansing soap is the first step to preventing acne (Movita, 2013). This research aims to formulate a facial wash preparation of sweet starfruit leaf extract (Averrhoa carambola L.) with good physical quality evaluation and the potential to inhibit the growth of Staphylococcus epidermidis bacteria. Sweet starfruit leaf powder (Averrhoa carmbola L.) was extracted using the maceration method and with 70% ethanol solvent. The resulting thick extract is tested for chemical content, ethanol free and specific gravity of the extract. Next, an evaluation of the preparation was carried out and an antibacterial activity test was carried out on a facial wash preparation of sweet star fruit leaf extract (Averrhoa carambola L.) with an extract concentration of FI 30%, FII 40%, FIII 50%, using the diffusion method, paper discs, Mueller Hinton Agar media. The results of this research show that starfruit leaf extract (Averrhoa carmbola L.) can be made into a good facial wash preparation and contains alkaloids, flavonoids, saponins, tannins and triterpenoids, which can act as antibacterials. In facial wash preparations, sweet starfruit leaf extract (Averrhoa carmbola L.) produces good physical quality and can inhibit Staphylococcus epidermidi bacteria at FI of 13.503mm±0.580, FII of 38.026mm±4.34 and FIII of 42.51mm±3.178. This shows that the higher the concentration of sweet starfruit leaf extract, the higher the inhibitory power produced
Copyright (c) 2023 Dewi Rahayu Utami, Gigih Kenanga Sari, Mingle A Pistanty https://creativecommons.org/licenses/by-sa/4.0
Antibacterial Activity Test of Cat's Whiskers Leaf Extract (Sauropus androgynus (L) Merr) Serum Preparation Against Propionibacterium acnes Bacteria
One of the inflammatory diseases that occurs in the pilosebaceous unit is acne. One of the bacteria that causes acne is Propionibacterium acnes. Katuk leaves contain flavonoids, saponins, tannins and alkaloids which can be used as an acne treatment. One of the pharmaceutical preparations that can be used to treat acne is serum. The aim of this research is to formulate katuk leaf extract into a serum preparation, determine the physical quality characteristics of the serum preparation and then determine the antibacterial activity against Propionibacterium acnes.The research method used is experimental. Katuk leaves were extracted by maceration method with 70% ethanol then serum preparations were made with various extract concentrations, namely FI 40%, FII 60% and FIII 80% on the basis of serum xanthan gum. The physical quality test of the serum preparation including organoleptic, pH, homogeneity, spreadability, adhesion and viscosity was carried out, then the antibacterial activity test of Propionibacterium acnes was carried out with positive control of clindamycin 10 µg/disk, negative control of 5% DMSO using disc diffusion method. The results of this study indicate that the formula has a semi-solid form, the color of FI is brownish green, FII is dark green and FIII is blackish green with a distinctive aroma of the extract, the formulation is homogeneous, has a pH, spreadability, adhesion and viscosity that meets the requirements of a good serum. The results of the antibacterial activity test showed that the negative control had no inhibition zone, the positive control showed a strong inhibition zone of 20.09 and the katuk leaf extract serum formulation had a moderate inhibition zone of FI 18.11, FII 19.21 and FIII 19.36 the greater the inhibition zone produced due to the higher concentration of the extract made. The results of statistical analysis of variations in extract concentrations showed significant differences in the inhibition zone based on One Way Anova statistical analysis (p<0.05).
Copyright (c) 2023 Maulina Nur Riskiani, Gigih Kenanga Sari, Maulita Saraswati https://creativecommons.org/licenses/by-sa/4.0
Serum Antibacterial Activity Test of Chinese Betel Extract (Peperomia Pellucida) Against Staphylococcus Aureus Bacteria
Chinese betel is a weed plant that contains antibacterial compounds such as flavonoids, saponins, tannins, triterpenoids and alkaloids which are used as acne treatment therapy. The aim of the research is to obtain a serum with good inhibitory power from varying concentrations of 5%, 10% and 15%. , then a stability evaluation was carried out including organoleptic tests, homogeneity, pH, viscosity, spreadability and stickiness as well as testing for antibacterial activity against the growth of Staphyloccocus aureus. Data analysis was carried out using One-Way ANOVA. The results obtained from the stability test have good standards for organoleptics, homogeneity, pH, viscosity, spreadability and adhesion. Antibacterial testing showed that the diameter of the inhibition zone formed against Staphyloccocus aureus bacteria was 15.71 mm, 18.94 mm and 23.06 mm. Based on the results obtained, Chinese betel serum has good stability and all formulas can inhibit the growth of the acne-causing bacteria Staphyloccocus aureus as evidenced by the diameter of the inhibition zone formed which is in the very strong category
Copyright (c) 2023 Asri Satrianingrum, Gigih Kenanga Sari, Mingle A Pistanty https://creativecommons.org/licenses/by-sa/4.0
Formulation and Antioxidant Test of Gotu Kola Leaf Ethanol Extract Cream (Centella asiatica)
Cosmetic products in the form of cream preparations containing antioxidant compounds have been developed to prevent premature aging of the skin. One of these plants is the gotu kola plant which can be used as a source of natural antioxidants. The active compounds contained in gotu kola leaves are flavonoids, alkaloids, saponins, tannins, triterpenoids, terpenoids which have been developed into dosage forms suitable for cream products. To determine the formulation of gotu kola leaf extract cream as an antioxidant. This research is experimental research. This experiment is based on extraction, formulation, preparation evaluation tests including organoleptic, pH, homogeneity, viscosity, spreadability, adhesive power. Then an antioxidant test was carried out. Statistical analysis was carried out using the ANOVA method. The research results show that gotu kola leaf extract can be formulated into cream preparations with various base variations that meet the requirements for good preparation evaluation. The antioxidant test results showed the IC50 FI value was 34.04 ppm, F2 30.27 ppm, F3 26.43 ppm. Statistical test results show significant antioxidant value, namely <0.05.
Copyright (c) 2023 adminagus adminagus; Vani Febri Rosiana, Maulita Saraswati, Wahyu Purwanjani https://creativecommons.org/licenses/by-sa/4.0
Testing the Antibacterial Activity of A Serum Preparation of Pegagan Leaf Extract (Centella asiatica (L.) Urban) Against the Bacteria Propionibacterium acnes
Centella asiatica (L.) Urban) is one of the wild plants and has various benefits to treat various health problems. Centella asiatica can be used as an antioxidant, antigastritis, antitumor, wound healing, immunomodulator, antiproliferation, antibacterial and so on. Purpose: To know that serum extract of Centella asiatica leaves can provide antibacterial activity of Propionibacterium acnes. Method: The research used is experimental. Centella asiatica (L.) Urban leaves were extracted by maceration with 70% ethanol. Centella asiatica (L.) Urban leaf extract was made into serum with concentrations of 5%, 10% and 15%. Physical stability tests were carried out including organoleptic, homogeneity, pH, spreadability, adhesion and viscosity, then tested for the antibacterial activity of Propionibacterium acnes. Statistical analysis was performed using the ANOVA method. Results: Research shows that gotu kola leaf extract contains chemical compounds including triterpenoids, saponins, flavonoids, alkaloids and tannins. The serum preparation formulation is yellowish green in color, has a distinctive extract odor and is in semisolid form, homogeneous during storage, has a pH, stickiness, spreadability, and viscosity that meet the requirements for a good serum. The results of the drag power research were F1 of 7.68% mm, F2 of 11.52 mm and F3 of 16.68 mm. The statistical test results showed a significant effect on antibacterial activity, namely <0.05.
Copyright (c) 2023 Bela Atika Putri, Gigih Kenanga Sari, Mingle A Pistanty https://creativecommons.org/licenses/by-sa/4.0
Formulation of Ethanol Extract Spray Gel Preparation of Sweet Starbumber Leaves (Averrhoa carambola L.)
The sweet star fruit leaf plant (Averrhoa carambola L.) is a plant that has many benefits, one part of the plant that is often used is the leaves which contain alkaloids, flavonoids, saponins and tannins that can be made indo spray gel preparations. Spray gel or commonly called spray gel is a gel that has an aqueous phase of 10-90% of the weight of the spray preparation. This research aims to formulate a spray gel preparation of ethanol extract of sweet starfruit leaves (Averrhoa carambola L.) by testing the physical stability of the spray gel preparation. The formulation of spray gel preparations of sweet starfruit leaf extract (Averrhoa carambola L.) with concentrations of 0.1%, 1% and 1.5% was researched using laboratory experimental methods. Physical stability tests of spray gel preparations include organoleptic tests, pH tests, homogeneity tests, viscosity tests, spray pattern tests, dry time tests, cycling tests and centrifugation tests.The results of testing the physical stability of spray gel preparations for each formula fall within the range of requirements for spray gel preparations. To test the physical stability of the spray gel preparation after the cycling test, the viscosity test and pH test for each formula showed a decrease in each formula, while the organoleptic test did not show a significant change in each formula after the cycling test. The centrifugation test results for each formula showed that it was stable, indicated by the absence of syneresis or phase separation. Based on research, it was found that at the highest concentration the spray gel preparation of ethanol extract of sweet star fruit leaves (Averrhoa crambola L.) had a good physical stability test.
Copyright (c) 2023 Eka Ammyta Putri Perdanti, Gigih Kenanga Sari, Maulita Saraswati https://creativecommons.org/licenses/by-sa/4.0
Testing the Activity of A Preparation of Katuk Leaf (Sauropus androgynus (L.) Merr.) Ethanol Extract Ointment on the Healing of Cut Wounds in Rabbits
Sauropus androgynus (L.) Merr. leaves are plants that contain secondary metabolite compounds that can be used as medicine in healing cuts. Objective: to determine the ethanol extract ointment of katuk leaves (Sauropus androgynus (L.) Merr.) for healing cuts in rabbits. Methode: the preparation of ointment preparations using the ethanol extract of katuk leaves (Sauropus androgynus (L.) Merr.) is identified for the compound content first then the ointment preparations are made. Tested using 3 (three) rabbits with 5 treatment groups, namely 10%, 12.5%, 15% katuk leaf ethanol extract ointment, positive control (10% povidone iodine), negative control (no extract base). All rabbits were injured with a length of 2cm to a depth of ± 0.2cm, each rabbit received 5 incision points. The wound is smeared 2 times a day every morning and evening. Wound observations were carried out every day for 14 days. Results Data analysis was carried out using One-Way ANNOVA. Results: Katuk leaf ethanol extract contains flavonoids, saponins and tannins. All ointment formulations have activity in healing cut wounds even though they have different healing times. Katuk leaf ethanol extract ointment meets the physical quality test requirements for ointments. The statistical test results showed that there was a significant difference in the healing of cut wounds in rabbits, namely (p<0.05). Conclusion: Katuk leaf ethanol extract ointment with a base concentration of 15% has the most optimal potential for healing cuts in rabbits.
Copyright (c) 2023 Poppy Ayu Holy Fitriana, Supriyanto, Wahyu Purwanjani https://creativecommons.org/licenses/by-sa/4.0
Suistanable Development Goals Protect Extinction of biodiversity Nepenthes sp
Nepenthes populations in nature are thought to be decreasing due to several factors such as forest fires, conversion of forest land or shrubs to residential areas, cultivation, plantations, agriculture or mining. The government has determined that Nepenthes is one of the priority plant species for protection because its presence in nature tends to be endangered. The existence of Nepenthes in their natural habitat has begun to be threatened due to several factors, including conversion into agricultural and mining lands, damage to natural habitats due to disasters or human actions, as well as over-exploitation. Based on these facts, Nepenthes plants are included in protected plants based on IUCN, WCMC, and Government Regulation N0. 7 of 1999 concerning Preservation of Plants and Animals. A study on the extinction of Nepenthes was carried out to find out the factors that influenced the extinction of this plant. The method used in this research is library search. Some previous research is used as a reference in this discussion in depth. The results show that there are several causes of the extinction of biodiversity for the pitcher plant, including habitat degradation, habitat fragmentation, exploitation, invasive species, and climate change. Real world programs and actions in the SGD's (Suistanable Development Goals) as an effort to protect the pitcher plant (Nepenthes sp.) from the threat of extinction of biodiversity is to carry out conservation efforts both in situ and ex situ.
Copyright (c) 2023 Mingle A Pistanty https://creativecommons.org/licenses/by-sa/4.0
Pemanfaatan Ekstrak Jagung (Zea Mays) di Kabupaten Grobogan Dalam Bentuk Sediaan Gel Sebagai Pelindung dari Sinar UVB
The purpose of this study was to produce a gel preparation with corn kernel extract as raw material, product profile information and the safety effects of using corn kernel extract gel preparation. The method used in this study with corn extract formulated into HPMC base with concentrations of 5%, 10%, and 20%. Then performed physical testing, the effect of the gel in rabbits and on the skin of human hands. This research produces a gel preparation with corn kernel extract as the raw material. The gel produced by increasing the concentration of HPMC can increase the viscosity, stickiness, and decrease the spreadability, but the increase in the concentration of HPMC does not affect the pH. The results of the effect test on the skin showed that corn extract gel could function as a skin protector from the sun, but the difference in HPMC concentration did not give a difference in the effect of protecting the skin from the sun. This study resulted in a conclusion in the form of a gel preparation with corn kernel extract as raw material, the product profile increased viscosity, gel adhesion, and also decreased dispersion, but the increase in HPMC concentration did not affect the pH of the preparation and the gel was safe as a skin protector from the sun.
Copyright (c) 2022 Gigih Kenanga Sari, Maulita Saraswati https://creativecommons.org/licenses/by-sa/4.0
EFEKKTIVITAS PEMBERIAN JUS BUAH ALPUKAT TERHADAP PENURUNAN KADAR KOLESTEROL DI DESA NGABENREJO GROBOGAN
Behind currently patients with heart disease tend to have increased from year to year, and this is in line with the progress of globalization is increasingly modern era many people forget the importance of a healthy lifestyle and healthy food consumption so that not a few people have high cholesterol levels in the blood. Hypercholesterolemia is a condition in which high levels of cholesterol in the blood exceeds 200 mg/dl. Avocado fruit juice therapy is one of management that can be used to lower cholesterol levels in a person who had hypercholesterolemia. This study of was to determine the effectiveness of feeding avocado fruit juice to decrease cholesterol levels in the village Ngabenrejo district of Grobogan. Research design used in this study is quasi experiment with methods one group pretest posttest. The technique sampling used is non- probability sampling as many as 15 respondents. Based on test results conducted found cholesterol levels to prior administration of the avocado fruit juice obtained an average value of 210.07 mg/dl where as cholesterol levels after administration of avocado fruit juice obtained an average value of 195.27 mg / dl. Test results of data analysis using paired t test results obtained on the sig (2-tailed) values obtained significansi 0.000 (p-value <0.05). Based paired t test results concluded that giving avocado fruit juice is effective in lowering cholesterol levels in the village Ngabenrejo district of Grobogan
Copyright (c) 2022 Pratama Medika : Jurnal Kesehatan
PENGARUH SOSIAL EKONOMI TERHADAP STATUS GIZI KURANG PADA BALITA DI KECAMATAN PURWODADI KABUPATEN GROBOGAN
Malnutrition is a condition where the nutritional needs of the body are not met within a certain period of time. Malnutrition is a major health problem worldwide. Globally, according to WHO, from data from around the world in 2018, around 7.3% or 49 million children under five years of age were undernourished. The prevalence of under-five children with malnutrition status in Indonesia is 13.8% and in Central Java Province the prevalence of under- nutrition is 14.0%. While in Grobogan Regency, it is known that there are 744 toddlers who experience malnutrition. This study aims to determine the effect of socio-economic on the nutritional status of under-fives in Purwodadi District, Grobogan Regency. The design in this study used a comparative descriptive and Case Control approach. The sampling technique used in this study was non- probability sampling with a total sampling method, and obtained 66 respondents, with 33 respondents in the case group with poor nutritional status and 33 respondents in the control group with good nutritional status. From the Chi- Square socio-economic test with poor nutritional status in toddlers, it is known that the p-value is 0.000 < 0.05 at 95% significance where ho is rejected, ha is accepted. So it can be concluded that there is a socio-economic influence on the nutritional status of under-fives in Purwodadi District, Grobogan Regency. There is a socio-economic influence on the nutritional status of under-fives in Purwodadi District, Grobogan Regency
STRATEGI DETEKSI DINI PENERAPAN MODEL PROMOSI KESEHATAN TERHADAP KEJADIAN KANKER SERVIKS DI WILAYAH PUSKESMAS BRATI
The incidence rate of cervical cancer in Central Java is 9.2%. Based on reports from health service agencies in Central Java, there were 7,029 cases in 2017 and in 2018 there were 7,029 cases. Early detection of cervical Ca with the IVA method in Central Java developed since 2007 the incidence of cervical cancer can be reduced by early detection. The purpose of this study was to determine the extent of the influence of health promotion, husband's support and information sources on early detection of cervical cancer, as well as the effective and relative contributions. This type of research uses quantitative research with a cross sectional approach, while the sampling technique is saturated sampling (census) where all members of the population are used as the research sample. The results of this study indicate a significant relationship between husband's support, health promotion, counseling with early detection of cervical cancer.
EFEKTIVITAS MASSAGE EFFLEURAGE TERHADAP PENURUNAN NYERI HAID
Menstrual pain or dysmenorrhea is pain during menstruation before or during menstruation. The incidence of dysmenorrhea in the world is very large. On average, more than 50% of women worldwide experience dysmenorrhea. The impact that occurs if dysmenorrhea is not treated can be a pathological condition (abnormality or disorder) that can or trigger an increase in mortality, including infertility. An easy treatment for dysmenorrhea is massage effleurage. The method of massage or massage on the abdomen with the effleurage technique is a form of skin stimulation that is used during the menstrual process to reduce pain effectively. The purpose of this study was to determine the effectiveness of effleurage massage on reducing menstrual pain. The type of research used is a quasi-experimental with a quantitative approach. The sampling technique used was consecutive sampling with a total of 30 respondents consisting of 15 respondents from the treatment group who were given effleurage massage, and 15 respondents who were the control group. The results of the study in the intervention group before the effleurage massage was done the average pain scale was 5.00 and after it was done 2.33. In the control group the average pain scale was 5.27 and after it was done it was 5.13. The results of the bivariate test in the group of respondents who were given effleurage massage after the Wilcoxon signed ranks test showed p value = 0.000 <0.05, which means that effleurage massage is effective in reducing menstrual pain.
HUBUNGAN PENGETAHUAN TENTANG COVID-19 DENGAN PENERAPAN PROTOKOL KESEHATAN MASYARAKAT DI RSUD DR. R.SOEDJATI SOEMADIARJO PURWODADI KABUPATEN GROBOGAN
Covid-19 is an unprecedented infectious disease. The Covid-19 virus is a virus that is transmitted to humans and attacks the respiratory system. This is a serious world problem with the number of cases always increasing. On March 11, 2020, the World Health Organization declared it a pandemic. One of the cities that is unavoidable from Covid-19, namely Grobogan Regency, it was found that the data update on the Grobogan Regency Kominfo situation on October 23, 2020 reported that 22 people were being treated in health facilities, 20 people were self-isolating and 78 people died. The act of implementing the health protocol is the key in preventing the spread of Covid-19, but many people do not implement it. This happens because of ignorance or unwillingness of the community to implement health protocols. Therefore, it is necessary to know about public knowledge with the application of health protocols during a pandemic. The purpose of this study was to determine the relationship between knowledge about Covid- 19 and the application of public health protocols at RSUD Dr. R. Soedjati Soemodiarjo Purwodadi, Grobogan Regency. The research method is a quantitative study using a cross sectional approach, the population of this study is the inpatient caretaker, the sampling technique used is non-probability sampling with accidental sampling technique and obtained a sample of 77 respondents. The results of the bivariate analysis obtained a p value (0.0000) < (0.05) and an R value of 1, which means that there is a relationship between knowledge about Covid-19 and the application of community protocols at Dr. R. Soedjati Soemodiarjo Hospital, Purwodadi, Grobogan Regency and has a strong correlation